I end up discussing sugar substitutes more often than I like with many of my patients. if people won't discontinue the sugary taste, I simply ask them to go back to a cane sugar cola, or even high fructose corn syrup.
I truly look at it as a rob peter to pay paul scenario, as splenda is nothing but chlorinated sugar, and nobody truly knows what it's doing to your physiology.
Aspartame is a perfect example, as many people have no clue that before it was branded as a sweetener, it had been manufactured as neurotoxin for warfare. In very dilute amounts they found it to be sweet, so they made it a product.
The less refined you can keep your food the better. Whenever I watch any of the popular shows, Top Chef all the way to Gordon Ramsey, they all go simple with no chemical junk.
Now the chemical gastronomy is interesting, but you won't find that situation with every day foods.
Stay natural, use natural sugar, honey

or stevia...and if anyone has any other suggestions for natural sweeteners I'd love to hear about them.